Inactivation of the Lysyl Oxidase Gene <i>Lox</i> Leads to Aortic Aneurysms, Cardiovascular Dysfunction, and Perinatal Death in Mice

Abstract

Lox has an essential role in the development and function of the cardiovascular system. Inactivation of the Lox gene causes structural alterations in the arterial walls, leading to abnormalities in the cardiovascular functions. Alterations in LOX activity may also play a critical role in certain human cardiovascular diseases.