Small · 2009 · 67 citations · 23 references
MedicineCancer BiologyOncologyBiomedical ImagingDiagnostic ImagingMolecular ImagingCancer BiomarkersFluorescence ImagingFluorescence MicroscopyImaging BiomarkersMolecular Imaging In OncologyQuantum DotsBioimagingCellular DistributionEmission SpectraMolecular Imaging Of CancerMultiplex Fluorescence ImagingOptical Imaging BiomarkersQuantum Dot FluorescenceQuantum Dot Imaging
Semiconductor quantum dots (QDs), which have broad absorption with narrow emission spectra, are useful for multiplex imaging. Here, fluorescence derby imaging using dual color QDs conjugated by the AS1411 aptamer (targeting nucleolin) and the arginine-glycine-aspartic acid (targeting the integrin alpha(v)beta(3)) in cancer cells is reported. Simultaneous fluorescence imaging of cellular distribution of nucleolin and integrin alpha(v)beta(3) using QDs enables easy monitoring of separate targets in the cancer cells and the normal healthy cells. These results suggest the feasibility of a concurrent visualization of QD-based multiple cancer biomarkers using small molecules such as aptamer or peptide ligands.
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In vivo cancer targeting and imaging with semiconductor quantum dots
Xiaohu Gao, Yuanyuan Cui, Richard M. Levenson et al. · Nature Biotechnology · 2004 · 4.7K citations
Nanocrystal targeting <i>in vivo</i>
Maria E. Åkerman, Warren C. W. Chan, Pirjo Laakkonen et al. · Proceedings of the National Academy of Sciences · 2002 · 1.4K citations · Full text
Crystal Structure of the Extracellular Segment of Integrin αVβ3
Jian-Ping Xiong, Thilo Stehle, Beate Diefenbach et al. · Science · 2001 · 1.3K citations · Full text