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Radionuclide Imaging of Metastases from Renal-Cell Carcinoma by<sup>131</sup>I-labeled Antitumor Antibody
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1978
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EngineeringOncologic ImagingRenal PathologyPathologyImmunotherapyOncologyGenitourinary CancerTheranosticsRadiopharmaceutical TherapyTherapeutic ImagingGoat AntiseraMolecular ImagingNuclear MedicineCancer ResearchRadiologyRadionuclide TherapyHistopathologyRadiologic ImagingMalignant DiseaseUrologyNormal Kidney131I-labeled AntibodyRadionuclide ImagingMedicine
On immunofluorescence assay, goat antisera reacted with renal-cell carcinomas from 20 patients, but not with adult normal human tissues (including patient's normal kidney). After in travenous injection, the 131I-labeled antibody localized preferentially in metastatic renal carcinoma in 6 consecutive patients. Labeled antitumor antibodies may have the specificity for tumor imagining which current radiopharmaceuticals lack.