Endothelial Cell Dysfunction in Mice After Transgenic Knockout of Type 2, but Not Type 1, 11β-Hydroxysteroid Dehydrogenase

Abstract

Although both 11betaHSD isozymes are present in the vascular wall, reactivation of glucocorticoids by 11betaHSD1 does not influence aortic function. Mice with 11betaHSD2 knockout, however, have endothelial dysfunction causing enhanced norepinephrine-mediated contraction. This appears to be independent of renal sodium retention and may contribute to hypertension in 11betaHSD2 deficiency.