Influence of Hypophysectomy and Growth Hormone on Cartilage Sulfate Metabolism.

Abstract

Hypophysectomy of immature growing rats results in a markedly diminished sulfate uptake of costal cartilage as judged from the cartilage to plasma inorganic sulfate specific activity ratios. The injection of growth hormone partially restore this ratio to normal under the conditions employed. The plasma inorganic sulfate specific activities of hypophysectomized rats are several fold higher than those of normal rats.