Technetium-99m-labeled HL91 to identify tumor hypoxia: correlation with fluorine-18-FDG.

Abstract

In this study, the use of 99mTc HL91 resulted in uptake in the majority of malignant tumors identified by 18F-FDG-PET. Technetium-99m HL91 exhibits good imaging characteristics, with imaging at 4 hr providing good lesion-to-normal tissue background ratios, that are further enhanced by SPECT.