The Laryngoscope · 1997 · 74 citations · 17 references
MedicineOtolaryngologyPharmacotherapyClinical PharmacologyNeurotologyOtologyMeniere DiseaseOtologic SurgeryAminoglycoside AntibioticsDrug-induced Hearing LossGentamicin TherapyIntratympanic TherapyMeniere Disease SurgeryMiddle Ear SurgerySurgical Management Of Vertigo
Topical administration of aminoglycoside antibiotics in the middle ear can achieve “chemical labyrinthectomy” in patients with intractable Meniere’s disease. The study reports outcomes of intratympanic gentamicin therapy in 21 patients with intractable Meniere’s disease using twice‑weekly and twice‑daily dosing protocols. Hearing and vertigo outcomes were assessed in the treated patients. Complete vertigo control was achieved in 95.2 % of patients initially, but 30 % relapsed within 12 months and 75 % of those responded to retreatment; hearing was preserved or improved in 62 %, worsened in 24 %, and unchanged in 14 %, with only 7.1 % hearing loss when cumulative dose ≤4 injections in the first week; overall, intratympanic gentamicin offers a better risk/benefit profile than other invasive therapies.
Topical administration of aminoglycoside antibiotics in the middle ear can achieve "chemical labyrinthectomy" in patients with intractable Meniere's disease. Herein we report our results of intratympanic gentamicin therapy in 21 patients using two different dosing protocols, twice weekly and twice daily (b.i.d.). Both hearing and vertigo outcome were evaluated. Complete control of episodic vertigo was achieved initially in 20 of 21 patients (95.2%). However, 6 of 20 responders (30%) developed relapsing symptoms within 12 months. Retreatment was successful in 75% of these patients. Overall, hearing was preserved or improved in 62% of cases, worse in 24%, and not yet tested in 14%. When the cumulative dose of gentamicin was < or = 4 injections in the first week, only 1 of 14 (7.1%) lost hearing. Intratympanic gentamicin offers better risk/benefit outcome than other invasive therapies for intractable Meniere's disease.
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Ablation therapy in the management of Menière's disease.
Schuknecht Hf · PubMed · 1957 · 229 citations
Medicine, Otolaryngology, Surgery +11
Clinical neurophysiology of the vestibular system
Richard R. Gacek · American Journal of Otolaryngology · 1990 · 142 citations
Biochemical Basis of Aminoglycoside Ototoxicity
Jochen Schacht · Otolaryngologic Clinics of North America · 1993 · 126 citations