Prevalence and spectrum of rheumatic diseases associated with proteinase 3‐antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase‐ANCA

Abstract

ANCA testing is useful due to its high sensitivity and specificity, especially for cANCA/PR3-ANCA in WG. We found a divergence in the disease spectrum between PR3- and MPO-ANCA-positive patients, characterized by higher DEI and extrarenal manifestations in the PR3-ANCA group. MPO-ANCA was rarely found in WG and was associated with less organ involvement.