Concepedia

Phase III Trial of Weekly Methotrexate or Pulsed Dactinomycin for Low-Risk Gestational Trophoblastic Neoplasia: A Gynecologic Oncology Group Study

Raymond Osborne, Virginia L. Filiaci, Julian C. Schink, Robert S. Mannel, Angeles Alvarez Secord, Joseph L. Kelley, Diane Provencher, David S. Miller, Allan Covens, Janice M. Lage

Journal of Clinical Oncology · 2011 · 189 citations · 18 references

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Abstract

The biweekly dactinomycin regimen has a higher CR rate than the weekly IM methotrexate regimen in low-risk GTN, a generally curable disease.

References

18

Low-Risk Persistent Gestational Trophoblastic Disease: Outcome After Initial Treatment With Low-Dose Methotrexate and Folinic Acid From 1992 to 2000

Iain A. McNeish, Sarah Strickland, L. Holden et al. · Journal of Clinical Oncology · 2002 · 245 citations

Combination but not single-agent methotrexate chemotherapy for gestational trophoblastic tumors increases the incidence of second tumors.

G.J.S. Rustin, E.S. Newlands, Jean Michel Lutz et al. · Journal of Clinical Oncology · 1996 · 184 citations

The role of low‐dose methotrexate and folinic acid in gestational trophoblastic tumours (GTT)

K. D. Bagshawe, J. Dent, E.S. Newlands et al. · BJOG An International Journal of Obstetrics & Gynaecology · 1989 · 146 citations

Single-agent methotrexate chemotherapy for the treatment of nonmetastatic gestational trophoblastic tumors

John R. Lurain, Elizabeth P. Elfstrand · American Journal of Obstetrics and Gynecology · 1995 · 103 citations

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Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy

John P. Roberts, John R. Lurain · American Journal of Obstetrics and Gynecology · 1996 · 91 citations

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