The effect of UV irradiation and photochemotherapy (PUVA) on histamine weal and flare in human skin

Abstract

Summary It is recognized that ultraviolet light has a beneficial effect in various inflammatory disorders of the skin. We have used histamine weal and flare as a model testing the effect of ultraviolet light on vascular response. No difference in weal and flare reaction following intradermal injection of 0·01-10·0 μg of hisiamine was found between covered and exposed skin following UV radiation or photochemotherapy (PUVA).