Identification of stereospecific [3H]spiroperidol binding sites in mammalian lymphocytes

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

PubMed · 1968 · 5.3K citations

Life Sciences, Cell Biology, Immunology +6

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

Ian Creese, David R. Burt, Solomon H. Snyder · Science · 1976 · 2.2K citations

Medicine, Neuroscience, Pharmacology +14

Antipsychotic drug doses and neuroleptic/dopamine receptors

Philip Seeman, T. Lee, M. Chau-Wong et al. · Nature · 1976 · 1.6K citations

Medicine, Pharmacology, Psychiatry +13

Serotonergic component of neuroleptic receptors

Josée E. Leysen, C. J. E. Niemegeers, J.P. Tollenaere et al. · Nature · 1978 · 626 citations

Life Sciences, Neuroscience, Pharmacology +14

Spiperone: A ligand of choice for neuroleptic receptors

Josée E. Leysen, W Gommeren, Pierre M. Laduron · Biochemical Pharmacology · 1978 · 544 citations

Medicine, Medicinal Chemistry, Pharmacology +12