Effect of ondansetron, a 5-HT ₃ receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study

Abstract

The 5-hydroxytryptamine receptor type 3 antagonist ondansetron had a significant positive effect on fatigue in CHC. These observations support the concept that fatigue involves serotoninergic pathways and may encourage further evaluations of the efficacy of ondansetron on fatigue in chronic liver diseases.