Acetamidoglycosylation with Glycal Donors: A One-Pot Glycosidic Coupling with Direct Installation of the Natural C(2)-N-Acetylamino Functionality

Abstract

Nitrogen transfer to glycals: A new method for direct C2-aza-glycosylation with glycal donors has been developed (see scheme), employing the new reagent combination of thianthrene-S-oxide and trifluoroacetic anhydride for glycal activation, in an overall one-pot procedure.