Vitamin B₁₂ Deficiency Associated with Histamine₂-Receptor Antagonists and a Proton-Pump Inhibitor

Abstract

The use of H(2)-receptor antagonists and/or PPIs may impair the absorption of protein-bound dietary vitamin B(12) and could contribute to the development of vitamin B(12) deficiency with prolonged use. Patients taking these medications for extended periods of time, particularly >4 years, should be monitored for vitamin B(12) status.