Decreased CD4+CD29+ (Memory T) Cells in Patients with Chronic Granulomatous Disease

Abstract

By the use of flow cytometry, 17 patients with chronic granulomatous disease (CGD) were examined for lymphocyte subsets. CD4+CD29+ cell (memory T cell) and CD8+CD11b+ cell (suppressor T cell) subsets in CGD were significantly decreased and remained practically unchanged throughout the period examined except in those < 6 months of age, although in controls both subsets gradually increased with age. These data indicate a certain abnormality in the maturation process of CGD T lymphocytes. Memory T cells are known to secrete a large amount of interferon-gamma (IFN-gamma). Recently, administration of IFN-gamma to CGD patients has become an effective treatment that reduces the frequency of serious bacterial infections. Decreased memory T cells may clarify the mechanism of therapeutic effectiveness, which remains unknown.