Kidney transplantation under FK 506 immunosuppression.

Abstract

We recently reported our initial experience with FK 506 in 36 patients undergoing renal transplantation.1 This series was characterized by a high average complexity, and included 10 patients who also were liver recipients either concomitantly or at an earlier time. Additionally, 2 of the 10 also were given a heart or pancreas. We report here a follow-up of the 26 patients from that original experience who were pure kidney recipients, plus 39 more treated through June 3, 1990. The first pure renal recipient underwent her third cadaveric transplantation on April 14, 1989. She was highly sensitized (panel reactive antibody [PRA] 93%) and rejected the graft. The next effort, also a retransplantation, was made on September 13, 1989. This was successful. Consequently, the follow-up to be reported of surviving grafts is 2.5 to 11 months.