Chirality Transfer from Epoxide to Carbanion: Base‐Induced Alkylation of <i>O</i>‐Carbamoyl Cyanohydrins of β‐Silyl‐α,β‐epoxy Aldehyde

Abstract

Abstract Enantioselective C–C bond formation at an α‐position of a nitrile group with an external electrophile can be realized, although in modest ee , with the aid of both the concerted process of an epoxysilane rearrangement and a carbamoyl group. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)