Neurology · 2006 · 23 citations · 7 references
Life SciencesNeurologyNeuroscienceMotor NeuroscienceMovement DisordersNeuropharmacologyCerebellar Control Of MovementCerebellar FunctionCerebellar Motor FunctionCerebellar PhysiologyNeurophysiology Of Movement Disorders3, 4-Diaminopyridine TherapyCerebellar Contributions To Movement DisordersDownbeat NystagmusModulation TechniquesNystagmus DisordersSlow Phase Velocity MeasurementVelocity Bias CorrectionVertical Positional Nystagmus
The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45 degrees ), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.
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Treatment of downbeat nystagmus with 3,4-diaminopyridine
Michael Strupp, Olaf G. Schüler, S. Krafczyk et al. · Neurology · 2003 · 244 citations
Medicine, Neurology, Pharmacology +15
Alexander's law: Its behavior and origin in the human vestibulo‐ocular reflex
David A. Robinson, David S. Zee, Timothy C. Hain et al. · Annals of Neurology · 1984 · 139 citations