Total Synthesis of Caprazol, a Core Structure of the Caprazamycin Antituberculosis Antibiotics

Abstract

TB and anti-TB: Two key steps in the synthesis of caprazol (1), a core structure of the antituberculosis antibiotics, are the introduction of an aminoribose moiety by β-selective ribosylation without the use of neighboring-group participation and the construction of the diazepanone moiety. Supporting information for this article (experimental details and characterization data for 3–16 and synthetic 2) is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462439_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.