Exploitation of Perfluorophenyl–Phenyl Interactions for Achieving Difficult Macrocyclizations by Using Ring‐Closing Metathesis

Abstract

Correct orientation: Macrocyclic paracyclophanes of multiple ring sizes and diverse functionality are prepared by olefin metathesis (see scheme for an example), through the exploitation of solution-phase quadrupolar interactions between the core arene and pendant pentafluoroarene units. This approach reverses the tendency for dimeric products to be formed during macrocyclizations.