Cross-platform comparison of glycan microarray formats

Linlin Wang, Richard D. Cummings, David F. Smith, Margaret E. Huflejt, Christopher T. Campbell, Jeffrey C. Gildersleeve, Jared Q. Gerlach, Michelle Kilcoyne, Lokesh Joshi, Sonia Serna,

Glycobiology · 2014 · 127 citations · 42 references

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TL;DR

Carbohydrates play key roles in biology, yet most glycan expression data come from antibody or lectin assays, making detailed reagent specificity essential for accurate analysis of glycan–protein interactions via microarrays. The authors compared six glycan microarray platforms using five lectins and introduced a universal threshold method to enable systematic cross‑platform comparisons. Using the universal threshold, the study identified the strongest binders for each lectin across all platforms, while weaker binders varied with platform‑specific presentation, array composition, and thresholding, providing a comprehensive dataset that informs glycan‑array deployment for GBP characterization.

Abstract

Carbohydrates participate in almost every aspect of biology from protein sorting to modulating cell differentiation and cell–cell interactions. To date, the majority of data gathered on glycan expression has been obtained via analysis with either anti-glycan antibodies or lectins. A detailed understanding of the specificities of these reagents is critical to the analysis of carbohydrates in biological systems. Glycan microarrays are increasingly used to determine the binding specificity of glycan-binding proteins (GBPs). In this study, six different glycan microarray platforms with different modes of glycan presentation were compared using five well-known lectins; concanavalin A, Helix pomatia agglutinin, Maackia amurensis lectin I, Sambucus nigra agglutinin and wheat germ agglutinin. A new method (universal threshold) was developed to facilitate systematic comparisons across distinct array platforms. The strongest binders of each lectin were identified using the universal threshold across all platforms while identification of weaker binders was influenced by platform-specific factors including presentation of determinants, array composition and self-reported thresholding methods. This work compiles a rich dataset for comparative analysis of glycan array platforms and has important implications for the implementation of microarrays in the characterization of GBPs.

References

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