Gnotobiotic Piglet Infection Model for Evaluating the Safe Use of Antibiotics against<i>Escherichia coli</i>O157:H7 Infection

Abstract

The increased in vitro toxin production caused by ciprofloxacin was strongly correlated with death and an increased rate of cerebellar hemorrhage, in contrast to the effect of azithromycin. The piglet is a suitable model for determining the effectiveness and safety of antibiotics available to treat patients.