Enhanced Ca ²⁺ -Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension

Abstract

The extracellular Ca(2+)-induced increase in [Ca(2+)](cyt) due to upregulated CaSR is a novel pathogenic mechanism contributing to the augmented Ca(2+) influx and excessive PASMC proliferation in patients and animals with pulmonary arterial hypertension.