Journal of General Virology · 1990 · 38 citations · 19 references
Veterinary MedicineImmunologyVeterinary MicrobiologyImmunizationMolecular VirologyMonoclonal AntibodiesAntibody-mediated ProtectionPoultry VirologyVeterinary ImmunologyVeterinary VaccinesViral Diseases Of PoultryViral VaccinesAdministration Of Monoclonal AntibodiesAvian Virus VaccinesBroiler ChickensNeutralizing Antibodies In PoultryPoultry VaccinesViral Immunity In PoultryViral Pathogenesis In PoultryVirus Characterization
A series of monoclonal antibodies (MAbs) against the haemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins and the matrix (M) protein of Newcastle disease virus (NDV) were tested for protective effects in passive immunization of newborn chickens against challenge with a virulent heterologous strain of NDV (Italien). MAbs with high virus-neutralizing activity directed to one antigenic site of the HN protein delayed virus growth and significantly prolonged survival time, but all chickens eventually succumbed to infection. MAbs directed to two antigenic sites of the F protein completely suppressed virus growth and prevented death of chickens, although the neutralizing activities of these anti-F MAbs were lower than those of the above anti-HN MAbs. Combined administration of the anti-HN and anti-F MAbs had a synergistic protective effect, but no protective effects were shown by MAbs against the M protein.
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Monoclonal antibodies protect against respiratory syncytial virus infection in mice.
Geraldine Taylor, E. J. Stott, M Bew et al. · PubMed · 1984 · 243 citations
Pascale Giraudon, Thorsten Wild · Virology · 1985 · 155 citations