Plasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains

Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

David A. Fidock, Takashi Nomura, Angela K. Talley et al. · Molecular Cell · 2000 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +12

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

David S. Peterson, David Walliker, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1988 · 657 citations · Full text

Life Sciences, Genetics, Pharmacology +17

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

Simon J. Foote, Jennifer K. Thompson, Alan F. Cowman et al. · Cell · 1989 · 569 citations

Life Sciences, Infectious Diseases, Molecular Genetics +16

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

Thomas E. Wellems, Lindsey J. Panton, Ilya Y. Gluzman et al. · Nature · 1990 · 558 citations

Life Sciences, Genetics, Infectious Diseases +14

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Alan F. Cowman, M J Morry, Beverley‐Ann Biggs et al. · Proceedings of the National Academy of Sciences · 1988 · 530 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16