Toxicology Methods · 2000 · 28 citations · 3 references
PharmacyDermatologyToxicologyAnalytical ToxicologyEnvironmental ToxicologyForensic ToxicologyChemical ExposureDose-exposure RelationshipsExposure AssessmentAssayEliminationGas Chromatography-mass SpectrometryNondestructive AssaySulfur ToxicityToxic Chemical ExposureToxicological Analysis Of UrineUrinary Excretion Rate
A case of accidental human exposure to sulfur mustard, the chemical warfare agent, was documented. The exposure produced skin damage in the form of erythema and blisters comprising less than 5% of the body surface area. Analytical methods verified and quantitatively analyzed the exposure by observing urinary thiodiglycol levels using gas chromatography-mass spectrometry. A maximum thiodiglycol urinary excretion rate of 20 μg/day was reached at day 3. Concentrations over 10 ng/mL were seen for as long as a week post exposure using the standard assay. First-order analysis of the elimination data yielded a thiodiglycol half-life of 1.2 d.
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