Gut · 2011 · 286 citations · 11 references
Although the reduction in CRC mortality was sustained, further follow-up of the screened population has not shown a significant reduction in the CRC incidence. Moreover, despite the removal of many large adenomas there was no reduction in the incidence of invasive cancer which was independent of sex and site of the tumour.
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Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood
Jack S. Mandel, John H. Bond, Timothy R. Church et al. · New England Journal of Medicine · 1993 · 3.2K citations · Full text
Randomised controlled trial of faecal-occult-blood screening for colorectal cancer
J D Hardcastle, J Chamberlain, Michael HE Robinson et al. · The Lancet · 1996 · 2.8K citations
The Effect of Fecal Occult-Blood Screening on the Incidence of Colorectal Cancer
Jack S. Mandel, Timothy R. Church, John H. Bond et al. · New England Journal of Medicine · 2000 · 1.4K citations · Full text