Growth of Neurotropic Viruses in Extraneural Tissues. I. MM Virus in the Feet of Hamsters

Abstract

After inoculation into the pad of the hind foot of a hamster, MM virus increases in amount in the local tissue. Subsequent increases in virus in the blood and viscera are in turn followed by appearance of the virus in the central nervous system. It appears certain that the virus grows in the foot. Whether the growth occurs in subcutaneous tissue, muscles, or nerve endings was not determined in these experiments.