A Functional Polymorphism in <i>IL-18</i> Is Associated with Severity of Bronchial Asthma

Abstract

Although the association results need to be replicated by other studies, IL-18 variants are significantly associated with asthma severity, and the rs5744247 variant reflects higher transcriptional activity and higher expression of IL-18 in LPS-stimulated monocytes and a higher serum IL-18 level.