Isolation and structure of narbonolide, narbomycin aglycone, from Streptomyces venezuelae and its biological transformation into picromycin via narbomycin

Abstract

A new crystalline compound, narbonolide (1), has been isolated from Streptomyces venezuelae MCRL 0376 and shown to be an aglycone of narbomycin (2) biologically convertible into picromycin (3)via narbomycin.