PuPHOS and CamPHOS Ligands in the Intermolecular Catalytic Pauson–Khand Reaction

Abstract

Abstract The first asymmetric intermolecular cobalt‐catalyzed Pauson–Khand reaction is described. The use of the hemilabile CamPHOS ligand provides good conversions and selectivity up to 28 % ee . The catalytic process was studied by in situ FT‐IR and it was found that both bridged and non‐bridged complexes were present in the reaction mixture. Our results suggest that recognition between the alkyne substrate and the ligand is essential to attain stereocontrol in the catalytic cyclization.