Urinary Albumin Excretion in Early and Long-Term Juvenile Diabetes

Abstract

When a radioimmunoassay for measuring urinary albumin excretion was used, the following results were obtained: In 11 normal male subjects a mean excretion rate of 9.7 g/min. during the day in the upright position was found. During the night, in the recumbent position, the excretion rate was significantly lower, with a mean value of 5.1 g/min. In 41 insulindependent male diabetic subjects without proteinuria the excretion rate was at the normal level, irrespective of the duration of diabetes. In 5 male patients with recently diagnosed juvenile diabetes, a significant fall in albumin excretion was found during treatment with insulin.