Intramedullary and Spinal Canal Tumors in Patients with Neurofibromatosis 2: MR Imaging Findings and Correlation with Genotype

Abstract

In patients with NF2 and spinal tumors, extramedullary tumors (predominantly NSTs) were present in higher numbers and were associated with more surgery than were intramedullary tumors. Our data suggest that the association between nonsense and frameshift mutations and severe NF2 may extend to specific categories of spinal tumors.