Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice

Abstract

Platelets have no direct impact on the pathogenesis of normothermic I/R injury. However, they mediate tissue repair and liver regeneration. Furthermore, platelet-derived serotonin is a mediator of hepatocyte proliferation in the postischemic liver, but has no impact on tissue remodeling.