pH effects on the cellular uptake of four photosensitizing drugs evaluated for use in photodynamic therapy of cancer

Acid pH in tumors and its potential for therapeutic exploitation.

Ian F. Tannock, Daniela Rotin · PubMed · 1989 · 1.6K citations

Pathology, Cell Proliferation, Cellular Physiology +19

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

L.E. Gerweck, Koushik Seetharaman · PubMed · 1996 · 1.1K citations

Pathology, Cancer Biology, Cellular Ph Gradient +17

THE PHOTODEGRADATION OF PORPHYRINS IN CELLS CAN BE USED TO ESTIMATE THE LIFETIME OF SINGLET OXYGEN

Johan Moan, Kristian Berg · Photochemistry and Photobiology · 1991 · 993 citations

Photobiology, Degradation Reaction, Redox Biology +16

PHOTOSENSITIZING EFFICIENCIES, TUMOR‐ and CELLULAR UPTAKE OF DIFFERENT PHOTOSENSITIZING DRUGS RELEVANT FOR PHOTODYNAMIC THERAPY OF CANCER

Johan Moan, Qian Peng, J. Evensen et al. · Photochemistry and Photobiology · 1987 · 200 citations

Partition Coefficient, Cell Inactivation, Photochemistry +15

Evidence for a major role of plasma lipoproteins as hematoporphyrin carriers in vivo

G. Jori, Mariano Beltramini, Elena Reddi et al. · Cancer Letters · 1984 · 191 citations

Biochemistry, Major Role, Physiology +11