Lofepramine and imipramine in unipolar depressed outpatients

Abstract

This is a double‐blind study involving 158 outpatients diagnosed ac‐cording to the DSM‐III as suffering from major depressive disorder. Both active drugs produced significantly more improvement than placebo on both physician and patient ratings, and lofepramine produced slightly less sedation and anticholinergic effects when compared with imipramine.