An Engineered Virus as a Scaffold for Three‐Dimensional Self‐Assembly on the Nanoscale

Abstract

Exquisite control over positioning nanoscale components on a protein scaffold allows bottom-up self-assembly of nanodevices. Using cowpea mosaic virus, modified to express cysteine residues on the capsid exterior, gold nanoparticles were attached to the viral scaffold to produce specific interparticle distances (see picture). The nanoparticles were then interconnected using thiol-terminated conjugated organic molecules that act as “molecular wires”, resulting in a 3D spherical conductive network, which is only 30 nm in diameter. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2421/2005/z500021_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.