Regiocontrolled lithiation of arenetricarbonylchromium (0) complexes: meta-substitution of phenols and anilines

Abstract

Tri-isopropylsilyl ethers of phenol- and aniline-tricarbonylchromium(0) complexes are lithiated predominantly meta to the heteroatom and subsequent reaction with suitable electrophiles produces overall meta-electrophilic substitution of phenols and anilines.