Differential Inhibition of Neuronal Na+–Ca2+Exchange versus Store-operated Ca2+Channels by Volatile Anesthetics in Pheochromocytoma (PC12) Cells

Abstract

These data indicate that volatile anesthetics, especially halothane and isoflurane, interfere with neuronal [Ca2+]i regulation by inhibiting NCX but not SOCC-mediated Ca2+ influx (except high concentrations of halothane).