The effects of ovariectomy and estrogen replacement on acetylcholine release from nerve fibres and passive stretch‐induced acetylcholine release in female rat bladder

Abstract

Our findings showed that as a results of estrogen deficiency, Ach release from nerve fibres decreased, suggesting that this reduction of Ach released from cholinergic nerves may cause the decrease in detrusor contractility. Furthermore, this study also demonstrated that stretch-induced TTX-insensitive Ach release was increased by ovariectomy. This may be a contributing factor to the development of overactive bladder in elderly women.