INHIBITION OF SPERMATOGENESIS IN THE RAT BY TREATMENT WITH [D-Ala⁶,DES-GLY-NH₂¹⁰]LHRH ETHYLAMIDE

Abstract

The effect of treatment with a potent LHRH agonist, [D-Ala6, Des-Gly-NH210]LHRH ethylamide, injected at the low dose of 100 ng, twice a week, was evaluated on spermatogenesis in the rat. Significant degenerative changes of seminiferous tubules could be observed after two weeks of treatment. These changes were progressive and led to a marked inhibition of spermatogenesis after four to eight weeks of treatment. Testis weight was decreased to approximately 50% of control after eight weeks of treatment.