<scp>IL</scp>‐23 Induces <scp>IL</scp>‐22 and <scp>IL</scp>‐17 Production in Response to <i><scp>C</scp>hlamydia muridarum</i> Genital Tract Infection, but the Absence of these Cytokines does not Influence Disease Pathogenesis

Abstract

IL-22 and IL-23 play either redundant or minimal roles in the pathogenesis of Chlamydia infection in the mouse model. Induction of Th17-associated cytokines by a Chlamydia vaccine should be avoided as these responses are not central to resolution of infection and have pathologic potential.