IEEE Transactions on Applied Superconductivity · 2008 · 43 citations · 9 references
EngineeringBioengineeringBiomedical EngineeringDrug DeliveryMagnetic MaterialsMedical PhysicsDrug Delivery EngineeringDrug Delivery SystemsMagnetic Field-responsive Drug DeliveryMagnetic-responsive Drug DeliveryNanomedicineSuperconducting Magnet SystemsBlood Vessel DistributionHigh-temperature SuperconductorsLocalized Magnetic TargetingMagnetic Drug Delivery SystemsMagnetic GuidanceMagnetically Guided Drug TargetingMagnetically Triggered Drug Delivery
A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.
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Locoregional cancer treatment with magnetic drug targeting.
Christoph Alexiou, W. Arnold, Robert J. Klein et al. · PubMed · 2000 · 869 citations
Pharmacy, Oncology, Pharmacology +17
Targeting cancer cells: magnetic nanoparticles as drug carriers
Christoph Alexiou, Roswitha J. Schmid, Roland Jurgons et al. · European Biophysics Journal · 2006 · 359 citations
Pharmacy, Oncology, Pharmaceutics +16
Fumihito Mishima, Shin‐ichi Takeda, Yuichi Izumi et al. · IEEE Transactions on Applied Superconductivity · 2006 · 48 citations · Full text
Fumihito Mishima, Shin‐ichi Takeda, Yoshinobu Izumi et al. · IEEE Transactions on Applied Superconductivity · 2007 · 41 citations · Full text