Cortistatin A is a High‐Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11

Abstract

Antiproliferative alkaloid: Cortistatin A is a high-affinity ligand for a small set of protein kinases including Rho-associated, coiled-coil-containing protein kinase (ROCK), cyclin-dependent kinase 8 (CDK8), and cyclin-dependent kinase 11 (CDK11). Models of cortistatin A bound to a crystallographic structure of ROCK (see picture) and a homology model of CDK8 are presented. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.