Lasers in Surgery and Medicine · 2000 · 194 citations · 23 references
Life SciencesBiophysicsPhysiologyBiomedical OpticsBiophotonicsCalcium HomeostasisBiomedical Laser ApplicationsCalcium SignalingHemodynamicsLaser-tissue InteractionMicrocirculatory PerfusionMicrocirculatory PhysiologyBlood FlowCytosolic Calcium SignalingLasersMicrocirculatory AlterationsRadiation Damage In Vascular TissueRadiation Effects On The Cardiovascular SystemVascular Smooth Muscle RegulationVascular Smooth Muscle Relaxation
BACKGROUND AND OBJECTIVE: Recently, there has been an increase in the clinical application of low-level laser irradiation (LLLI) in various fields. The present study was conducted to explore the effects of LLLI on microcirculation. STUDY DESIGN/MATERIAL AND METHODS: We investigated the effects of LLLI on rat mesenteric microcirculation in vivo, and on cytosolic calcium concentration ([Ca2+]i) in rat vascular smooth muscle cells (VSMCs) in vitro. RESULTS: LLLI caused potent dilation in the laser-irradiated arteriole, which led to marked increases in the arteriolar blood flow. The changes were partly attenuated in the initial phase by the superfusion of 15 microM L-NAME, but they were not affected by local denervation. Furthermore, LLLI caused a power-dependent decrease in [Ca2+]i in VSMCs. CONCLUSION: The circulatory changes observed seemed to be mediated largely by LLLI-induced reduction of [Ca2+]i in VSMCs, in addition to the involvement of NO in the initial phase.
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Effect of laser rays on wound healing
E Mester, T Spiry · The American Journal of Surgery · 1971 · 705 citations
Medicine, Dermatology, Surgery +14
Relief from chronic pain by low power laser irradiation
Judith Walker · Neuroscience Letters · 1983 · 328 citations