Identification of <i>PCDH1</i> as a Novel Susceptibility Gene for Bronchial Hyperresponsiveness

Abstract

PCDH1 is a novel gene for BHR in adults and children. The identification of PCDH1 as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium, the first line of defense against inhaled substances, contributes to the development of BHR.