Annals of Neurology · 1998 · 239 citations · 11 references
MedicinePathobiologyPathologyCellular PathologyHistologyHistopathologyCervical HistologyCervical PathologyConnective TissueConnective Tissue DiseasesConnective Tissue DisordersCutaneous Connective Tissue DisordersCervical Arterial DissectionCervical Artery DissectionConnective Tissue Disorder PathogenesisConnective Tissue Disorder SyndromesConnective Tissue MatrixUltrastructural AlterationsUltrastructural Pathology
The cause of spontaneous cervicocerebral artery dissection is unknown. An underlying arteriopathy due to a connective tissue disorder has often been presumed. We studied 25 patients with proven nontraumatic dissections. The ultrastructural morphology of dermal connective tissue components was assessed by transmission electron microscopy of skin biopsies. Ultrastructural abnormalities were seen in 17 (68%) patients, resembling in some cases the aberrations found in Ehlers-Danlos syndrome type II or III. These observations indicate a correlation of cervical artery dissections with connective tissue abnormalities. A structural abnormality in the extracellular matrix potentially caused by basic molecular defects is suggested and warrants further exploration.
11
Stroke–Pathophysiology, Diagnosis, and Management
Wink S. Fisher · Neurosurgery · 1993 · 308 citations
Medicine, Neurology, Neuroscience +12
Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II.
Anne De Paepe, Lieve Nuytinck, I. Anton‐Lamprecht et al. · PubMed · 1997 · 166 citations