Equilibrium between Adenylyl Cyclase and Phosphodiesterase Patterns Adrenergic Agonist Dose-Dependent Spatiotemporal cAMP/Protein Kinase A Activities in Cardiomyocytes

Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

Manuela Zaccolo, Tullio Pozzan · Science · 2002 · 838 citations

Second Messenger, Cardiac Muscle, High Concentration +16

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

Marco Mongillo, Theresa McSorley, Sandrine Evellin et al. · Circulation Research · 2004 · 381 citations · Full text

Cardiac Muscle, Biophysical Modeling, Pde Isoenzymes +21

Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters

Michael D. Allen, Jin Zhang · Biochemical and Biophysical Research Communications · 2006 · 291 citations

Protein Function, Signal Transduction, Signaling Pathway +15

Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Marco Mongillo, Carlo G. Tocchetti, Anna Terrin et al. · Circulation Research · 2005 · 273 citations · Full text

Cardiac Muscle, Neuropeptides, Camp Generation +19

β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics

Jonathan D. Violin, Lisa M. DiPilato, Timothy C. Elston et al. · Journal of Biological Chemistry · 2007 · 260 citations · Full text

Homeostatic Mechanism, Improved Fluorescent Biosensor, Cellular Physiology +21