Measurement of ampicillin, vancomycin, linezolid and gentamicin activity against enterococcal biofilms

Abstract

Very high concentrations of ampicillin, vancomycin and linezolid are required to inhibit enterococcal biofilms in vitro. Combining these agents with gentamicin significantly reduced MIC, MBC and MBIC against only a proportion of enterococcal isolates. No correlation between MBIC and outcome was found.