Synthesis of Some New Fu Sed/Spiro of Benzoindole Derivatives and Their Biological Activity

Abstract

Abstract A series of fused and spiropyrazolones, pyrimidinthiones, thiazolidinones and β‐lactams incorporating benzoindole derivatives have been synthesised by cyclocondensation addition reaction and cycloaddition reaction of hydrazine hydrate, hydroxylamine, thiourea, mercapto acetic acid and monochloroacetyl chloride. The pre pared com pounds were tested for anti bacterial and fungicidal activity. Gram‐negative bacteria (Bacilluscereus), as well as the fun gus was used for this purpose. The biological assay was determined according to the filter paper disc method. Assay plates were incubated at 30°C one day for the bacteria and three days for the fun gus (British pharmacopoeia commisson, 1102m, London 1963). The test results show that the components have a strong and sat is factory effect.